Nuclear lamina

From Academic Kids

The nuclear lamina is the dense, fibrillar network composed of intermediate filaments made of lamin that lines the inner surface of the nuclear envelope. This network of filaments is essential for the disarrangement of the nuclear envelope into vesicles during mitosis or meiosis, and its posterior reassembly. When, during the cell cycle, a certain cyclin-dependent kinase complex phosphorylates the lamins they undergo a conformational change that triggers the disassembly of the nuclear envelope. After the chromosomes have migrated to each pole, dephosphorylation of lamins causes the nucleus to reassemble.

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